The Toxic Dose of Nicotine: Shattering the Myth. The initial port of call in any discussion similar to this is to address a long-standing myth. Even today, many high-profile sources list the toxic dose of nicotine (the LD50 – or the dose that will kill about half of people exposed) as between 30 and 60 mg.
To place this in context of Vapor Cigs Store, this is about 4 ml of 12 mg/ml e-liquid. The body does process nicotine quite quickly (your blood nicotine levels will decrease by about 50 % after two hours), so you’d need to consume it all basically all at once, which makes it still quite a tall order.
However, research by Bernd Mayer indicates this value for that toxic dose is completely indefensible. Inside the paper, he details several cases in which people consumed larger levels of nicotine with only minimal symptoms. On top of this, the best amount of nicotine based in the blood of people who died from nicotine was about 20 times more than existing guidelines. Mayer revises the LD50 of nicotine to an estimated 500 to 1000 mg (or .5 to 1 g) on the basis of such results.
The rest of the real question is where did the “30 to 60 mg of nicotine will kill you” claim come from? Mayer followed “circular and quite often misleading references” for some time and ultimately hit on the source: a 1906 textbook coming from a German toxicologist.
With this basis alone, it’s clear that there are probably some issues with trusting this as a source. He was a respected toxicologist at that time, but medical knowledge has advanced massively in the century since it was published, therefore it isn’t surprising that repeating this claim verbatim with no further analysis isn’t the most effective idea.
The textbook cited some self-experiments performed in the nineteenth century, where experimenters had the equivalent of a few cigarettes’ amount of nicotine and reported seizures and loss in consciousness. It goes without stating that there is probably some error in measuring the dose: otherwise chain-smokers would regularly lose consciousness and also have seizures.
Signs You’ve Had A Lot Of Nicotine. Vapers aren’t very likely to suffer nicotine poisoning, but one thing that’s fairly common has a touch too much nicotine in just one sitting. The biggest tell-tale sign you’ve reached this time is feeling nauseous. You could notice this towards the end of the long vaping session, and it’s effectively your system suggesting to have a break from vaping for a while.
Inside my experience, this nausea increases gradually, but it’s better to just have a break whenever you notice it starting. In this way it never becomes too unpleasant, and also you won’t experience the most important other initial symptom: vomiting. This isn’t tough to avoid whatsoever, and a lot vapers will have a break in the first indication of nausea even without having to be advised to do this. You might also obtain a headache if you’ve overdone it somewhat, but nausea is definitely the easiest thing to watch out for.
It’s unlikely you’ll actually reach this stage by vaping, but it’s worth knowing a few things to look out for. By far the most serious nicotine poisoning symptoms are even less prone to occur when you’re vaping, but they are worth mentioning anyway. Included in this are coma and seizures (like our 19th century experimenters experienced), slowed heartrate and in the worst cases, respiratory failure. It might not be as poisonous as many sources claim, nevertheless it certainly is still poisonous.
Are You Able To Get Nicotine Poisoning by Vaping? For vapers, the most important question for you is whether this is really something to concern yourself with in practice. Would you vape your way to your nicotine overdose? Could you find yourself with some of the much more serious signs and symptoms of nicotine poisoning?
The easiest way to consider this (and to acquire a straightforward answer!) is to determine how much e-juice you’d have to vaporize within the space of a couple of hours going to the minimum toxic dose of about 500 mg.
Employing a 12 mg/ml e-juice, you’d have to vaporize over 40 ml to approach 500 mg of nicotine vaporised. Realistically, this just isn’t going to take place. For an 18 mg/ml e-liquid, you’d still have to vape almost 28 ml of e-juice in a number of hours to even have a chance.
This is really only the initial step, though, and the nicotine would have to get into the vapour and be absorbed by your body before it might poison you.
Estimating this aspect is a bit tough, but a study from Dr. Farsalinos looked at experienced vapers’ plasma nicotine levels after using a mod plus an 18 mg/ml e-liquid. The research didn’t make use of a modern device, but to answer the true secret question here it’s a lot more than sufficient. The participants vaped 10 puffs in 5 minutes, then had one hour to djurpj the product however much they liked.
After a few minutes, experienced vapers ended up with about 8 nanograms (billionths of any gram) of nicotine per ml of blood. Following the full 65 minutes, vapers plasma nicotine levels rose to 24.1 ng/ml, though the highest recorded concentration was 48.1 ng/ml.
In Bernd Mayer’s paper, he indicates the minimum plasma concentration recorded from someone who died from nicotine overdose was 4,000 ng/ml (comparable to 4 mg per liter).
Based on the vaper who got the best plasma nicotine levels, their blood nicotine level would have to be over 80 times higher to arrive at the minimum lethal dose. To pile on yet more implausibility, they’d have to achieve this in less than a couple of hours. In other words, they’d need to get about 80 times more nicotine in their blood in under twice how long.
This should clearly demonstrate that vapers really can’t overdose on nicotine by utilizing their e-cigarettes as intended. It seems like unlikely that it’d even be physically possible to inhale as much vapour as you’d have to.